INNOVATIVE TRIZ-BASED APPROACH TO PREVENT CLDE SYMPTOMS IN SILICONE-HYDROGEL EYE CONTACT LENSES
Since the invention of a very first eye contact lens in 1887, as an alternative to conventional glasses, drastic changes has been implied into the material, structure, shape and other parameters of eye contact lenses. Nowadays eye contact lenses are used by over 150 million people worldwide for corrective, cosmetic and therapeutic purposes. The most popular modern eye contact lenses are made from silicon and hydrogel. Silicon makes up the channels inside the lens through which oxygen, water and nutrients are going to the cornea, while hydrogel as a highly hydrophilic gel adsorbs water and maintains soft structure of the lens which is necessary for normal functioning of the eye. Although both components are necessary in the eye contact lens, they cause negative effects such as increased evaporation due to porous structure and water adsorption from tear film, that is critical for maintaining moisture on the eye surface. Combination of these effects ultimately lead to the occurrence of contact lens-related dry eye syndrome (CLDE), that is experienced by about 50% of contact lens wearers. Our goal is to apply TRIZ-based approaches to develop an innovative structure of eye contact lenses that will prevent the occurrence of CLDE. After thorough study of the mechanisms triggering CLDE the technical contradiction and physical contradiction of the core problem were identified. Cause-effect chain Analysis (CECA) and function diagram played the key role in transitioning from the problem to the possible solutions. Various ideas of improvement were suggested through the specifics of application of different TRIZ tools in accordance with ARIZ85C. Conclusively, TRIZ can be a potential breakthrough if incorporated as a solving method for medical, biological, biochemical and other related areas.
Guillon M. Tear film examination of the contact lens patient. OPTICIAN-SUTTON- 1993; 206: 21.
Efron N. Contact Lens Practice E-Book. Elsevier Health Sciences: Queensland University of technology, 2016.
Bühler N, Haerri H, Hofmann M, Irrgang C, Mühlebach A, Müller B, Stockinger F. Nelfilcon A, a new material for contact lenses. CHIMIA International Journal for Chemistry 1999; 53 (6): 269-274.
Goldenberg M. Polyoxirane crosslinked polyvinyl alcohol hydrogel contact lens. Polyoxirane crosslinked polyvinyl alcohol hydrogel contact lens (US4598122A) (1986).
Wichterle O, Lim D. Hydrophilic gels for biological use. Nature 1960; 185 (4706): 117-118. DOI: 10.1038/185117a0.
Mitchell DD. Wettable silicone resin optical devices and curable compositions therefor. Wettable silicone resin optical devices and curable compositions therefor (US4487905A) (1984).
Morgan PB, Woods CA, Tranoudis I, Helland M, Efron N, Jones L, Davila-Garcia E, Magnelli P, Teufl I, Grupcheva CN. International contact lens prescribing in 2014. Contact Lens Spectrum 2015; : 28-33.
Orsborn G, Dumbleton K. Eye care professionals’ perceptions of the benefits of daily disposable silicone hydrogel contact lenses. Contact Lens and Anterior Eye 2019; 42 (4): 373-379. DOI: 10.1016/j.clae.2019.02.012.
Fonn D, Dumbleton K, Jalbert I, Sivak A. Benefits of silicone hydrogel lenses. Contact Lens Spectrum 2006; 21 (I): 38.
Awasthi AK, Meng FR, Künzler JF, Linhardt JG, Papagelis P, Oltean G, Myers SA. Ethylenically unsaturated polycarbosiloxanes for novel silicone hydrogels: synthesis, end‐group analysis, contact lens formulations, and structure–property correlations. Polymers for Advanced Technologies 2013; 24 (6): 557-567. DOI: 10.1002/pat.3115.
Tran N, Yang M. Synthesis and characterization of silicone contact lenses based on TRIS-DMA-NVP-HEMA hydrogels. Polymers 2019; 11 (6): 944. DOI: 10.3390/polym11060944.
Thai LC, Tomlinson A, Doane MG. Effect of contact lens materials on tear physiology. Optometry and Vision Science 2004; 81 (3): 194-204.
Sweeney DF. Have silicone hydrogel lenses eliminated hypoxia? Eye & contact lens 2013; 39 (1): 53-60. DOI: 10.1097/ICL.0b013e31827c7899.
Markoulli M, Kolanu S. Contact lens wear and dry eyes: challenges and solutions. Clinical optometry 2017; 9: 41. DOI: 10.2147/OPTO.S111130.
Imafuku S. Silicone hydrogel soft contact lens having wettable surface. Silicone hydrogel soft contact lens having wettable surface (US10241234B2) (2019); .
Craig JP, Willcox MD, Argüeso P, Maissa C, Stahl U, Tomlinson A, Wang J, Yokoi N, Stapleton F. The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the tear film subcommittee. Investigative ophthalmology & visual science 2013; 54 (11): TFOS123-TFOS156. DOI: 10.1167/iovs.13-13235.
Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Survey of ophthalmology 2001; 45: S203-S210. DOI: 10.1016/S0039-6257(00)00203-4.
Argüeso P. Glycobiology of the ocular surface: mucins and lectins. Japanese journal of ophthalmology 2013; 57 (2): 150-155. DOI: 10.1007/s10384-012-0228-2.
García-Montero M, Rico-del-Viejo L, Llorens-Quintana C, Lorente-Velázquez A, Hernández-Verdejo JL, Madrid-Costa D. Randomized crossover trial of silicone hydrogel contact lenses. Contact Lens and Anterior Eye 2019; 42 (5): 475-481. DOI: 10.1016/j.clae.2018.12.006.
Guillon M, Styles E, Guillon J, Maissa C. Preocular tear film characteristics of nonwearers and soft contact lens wearers. Optometry and vision science: official publication of the American Academy of Optometry 1997; 74 (5): 273-279. DOI: 10.1097/00006324-199705000-00022.
Sharma A, Ruckenstein E. Mechanism of tear film rupture and formation of dry spots on cornea. Journal of colloid and interface science 1985; 106 (1): 12-27. DOI: 10.1016/0021-9797(85)90375-3.
Kojima T. Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan. Investigative ophthalmology & visual science 2018; 59 (14): DES102-DES108. DOI: 10.1167/iovs.17-23685.
Havuz E, Gurkaynak MN. Videokeratoscopic assessment of silicone hydrogel contact lens wettability using a new in-vitro method. Contact Lens and Anterior Eye 2019; 42 (6): 614-619. DOI: 10.1016/j.clae.2019.07.005.
Andrasco G. The effect of humidity on the dehydration of soft contact lenses on the eye. Int Cont Lens Clin 1980; 7: 210-212.
BrennanM NA, Efron N, Truong VT, Watkins RD. Definitions for hydration changes of hydrogel lenses. Ophthalmic and Physiological Optics 1986; 6 (3): 333-338. DOI: 10.1111/j.1475-1313.1986.tb00725.x.
Kojima T, Matsumoto Y, Ibrahim OM, Wakamatsu TH, Uchino M, Fukagawa K, Ogawa J, Dogru M, Negishi K, Tsubota K. Effect of controlled adverse chamber environment exposure on tear functions in silicon hydrogel and hydrogel soft contact lens wearers. Investigative ophthalmology & visual science 2011; 52 (12): 8811-8817. DOI: 10.1167/iovs.10-6841.
Fornasiero F, Prausnitz JM, Radke CJ. Post-lens tear-film depletion due to evaporative dehydration of a soft contact lens. Journal of Membrane Science 2006; 275 (1-2): 229-243. DOI: 10.1016/j.memsci.2005.09.047.
Dutta D, Kamphuis B, Ozcelik B, Thissen H, Pinarbasi R, Kumar N, Willcox MD. Development of silicone hydrogel antimicrobial contact lenses with Mel4 peptide coating. Optometry and Vision Science 2018; 95 (10): 937-946. DOI: 10.1097/OPX.0000000000001282.
Filipecki J, Sitarz M, Kocela A, Kotynia K, Jelen P, Filipecka K, Gaweda M. Studying functional properties of hydrogel and silicone–hydrogel contact lenses with PALS, MIR and Raman spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014; 131: 686-690. DOI: 10.1016/j.saa.2014.04.144.
Orloff MA. ABC-TRIZ: Introduction to Creative Design Thinking with Modern TRIZ Modeling. Springer, 2016.
Zlotin E, Petrov V. Introduction to the Theory of Inventive
Problem Solving. Tel-Aviv: TRIZ-Isr@ bigfoot.com 1999; : 351.
Wang J. The Improved Study of TRIZ Innovative Design Method. Department of Mechanical Engineering, National Cheng Kung University, Taiwan 2002; .
Mahto DG. Concepts, tools and techniques of problem solving through TRIZ: A review. International Journal of Innovative Research in Science, Engineering and Technology 2013; 2 (7).
Marconi J, Works M. ARIZ: the algorithm for inventive problem solving. The TRIZ Journal 1998; .
MATRIZ – Level 1 Training Manual. https://matriz.org/wp-content/uploads/2019/01/Level-1-Manual-Word.pdf .
John Terninko, Ellen Domb and Joe Miller. The seventy-six standard solutions, with examples section one (2000);
ARIZ 85C Part 4. https://www.altshuller.ru/triz/ariz85v-4.asp#3
Krot AY. Application of Altshuller Method for Resolution of Technical Contradictions. : 260-261, (2017); .
Tate K, Domb E. How to Help TRIZ Begineers Succeed. TRIZ Journal 1997;
Gareev RT. TRIZ Heuristic Techniques: A Training Manual. Moscow State Industrial University, 2008.
Genrich Altshuller. Algorithm of Invention. Moscow worker, 1973.
Tiffany JM. The viscosity of human tears. International ophthalmology 1991; 15 (6): 371-376. DOI: 10.1007/BF00137947.
Chandler D. Hydrophobicity: Two faces of water. Nature 2002; 417 (6888): 491. DOI: 10.1038/417491a.
Becattini N, Borgianni Y, Cascini G, Rotini F. ARIZ85 and Patent-driven Knowledge Support. Procedia engineering
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