Marian RĂDULESCU, Horia MOCANU, Alexandru NECHIFOR, Adela Ioana MOCANU


The analysis employes Claude Bernard’s physiological method of establishing the function of internal organs to reinterpret a classical experiment by Yee A.L. & Cantekin E.I. The surprising results could only be explained by the existence of the D-Organ (The Danaïdes Organ) which we define within the middle-ear (ME) and compare to the Eustachian tube (ET) in terms of middle-ear ventilation. Its function could only be completely defined via a physical-mathematical model. The ventilation of the middle-ear is therefore achieved by the D-Organ, a biological pump, consuming metabolic energy to move gases against pressure gradients and the F-Organ with role in passive diffusion of gas using pressure gradients, in accordance to Fick’s law.

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Conti, F. Claude Bernard: primer of the second biomedical revolution. Nat Rev Mol Cell Biol; 2(9), pp.703-8, 2001.

Yee, A.L. and Cantekin, E.I. Effect of Changes in Systemic Oxygen Tension on Middle Ear Gas Exchange. Ann Otol Rhinol Laryngol; 95(4,1), pp.369-372, 1986.

Alecu, I., Mocanu, H. and Călin, I.E. Intellectual mobility in higher education system. Rom J Mil Med; CXX (2), pp.16-21, 2017.

Piiper, J. Physiological Equilibria of Gas Cavities in the Body. In: Fenn, W.O., Rahn, H., Section 3 Editors. Respiration, Handbook of Physiologie, A Critical Comprehensive Presentation of Physiological Knowledge and Concepts. Washington DC: American Physiological Society 2(48), pp.1205-1218, 1965.

Best, C.H. and Taylor, N.B. The physiological basis of medical practice, A text in applied physiology. 6th Edition, The Williams & Williams Company, Baltimore; Part III, Chapter 31, 1955.

Guyton, A.C. Textbook of Medical Physiology. Eight Edition, Philadelphia: WB Saunders Company, Harcourt Brace Jovanovich Inc; pp. 2,274,433-437,744,792, 1991.

Felding, U.N., Banks, J.M. and Doyle, W.J. Middle Ear Gas Exchange in the Air Phase. Acta Oto Laryngol; 123, pp.808-11, 2003.

Mocanu, H., Mocanu, A.I., Drăgoi, A.M. and Rădulescu, M. Long-term histological results of ossicular chain reconstruction using bioceramic implants. Exp Ther Med; 21(3), pp.262, 2021. DOI: 10.3892/etm.2021.9692.

Sadé, J. and Luntz, M. Middle Ear as a Gas Pocket. Ann Otol Rhinol Laryngol; 99, pp.529-534, 1990.

Ikarashi, F., Takahashi, S., Yamamoto, Y. Carbon Dioxide Exchange via the Mucosa in Healthy Middle Ear. Arch Otolaryngol Head Neck Surg; 125, pp. 975-8, 1999.

Buckingham, R., Stuart, D.R. and Girgis, S.J. Experimental evidence against middle ear oxygen absorption. Laryngoscope; 95, pp.437-42, 1985.

Mover-Lev, H., Levy, D., Luntz, M., Harell, M., Ar, A. and Sadé, J. Dependence of middle ear gas composition on pulmonary ventilation. Ann Otol Rhinol Laryngol; 106, pp.314-9, 1997.

Hergils, L. and Magnuson, B. Regulation of negative middle ear pressure without tubal opening. Arch Otolaryngol Head Neck Surg; 114, pp.1442-4, 1998.

Shinkawa, H., Okitsu, T., Yusa, T., Yamamuro, M. and Kaneko, Y. Positive intratympanic pressure in the morning and its etiology. Acta Otolaryngol (Stockh); 435, pp.107-111, 1987.

Doyle, W.J. and Seroky, J.T. Middle ear gas exchange in rhesus monkeys. Ann Otol Rhinol Laryngol; 103, pp.636-45, 1994.

Sadé, J., Luntz, M. and Levy, D. Middle ear gas composition and middle ear aeration. Ann Otol Rhynol Laryngol; 104, pp.369–373, 1994.

Luntz, M., Levy, D., Sadé, J. and Herman, M. Relationship between the gas composition of the middle ear and the venous blood at steady state. Laryngoscope; 105, pp.510-2, 1995.

Tideholm, B., Carlborg, B., Jönsson, S. and Bylander-Groth, A. Continuous long-term measurements of the middle ear pressure in subjects without a history of middle ear disease. Acta Otolaryngol (Stockh); 118, pp.369-375, 1998.

Yamamoto, Y. Gas exchange function through the middle ear mucosa in piglets: comparative study of normal and inflamed ears. Acta Otolaryngol (Stockh); 119, pp.72-7, 1999.

Mocanu, H. and Oncioiu, I. The Influence of Clinical and Environmental Risk Factors in the Etiology of Congenital Sensorineural Hearing Loss in the Romanian Population. Iran J Publ Health; 48, pp.2301-3, 2019.

Mocanu, H. The role of perinatal hearing screening in the normal development of the infant’s language. In: Debating Globalization. Identity, Nation and Dialogue 4th Edition. Boldea I, Sigmirean C (ed.) Arhipelag XXI Press, Tirgu Mures; pp.562-569, 2017.

Neagu, A., Mocanu, A.I., Bonciu, A., Coadă, G. and Mocanu, H. Prevalence of GJB2 gene mutations correlated to presence of clinical and environmental risk factors in the etiology of congenital sensorineural hearing loss of the Romanian population. Exp Ther Med; 21(6), pp. 612, 2021. DOI: 10.3892/etm.2021.10044.

Mocanu, H. The economic impact of early diagnosis of congenital hearing loss. In: Debating Globalization. Identity, Nation and Dialogue 4th Edition. Boldea I, Sigmirean C (ed.) Arhipelag XXI Press, Tirgu Mures; pp. 556-561, 2017.

Neudert, M., Bornitz, M., Mocanu, H., Lasurashvili, N., Beleites, T., Offergeld, C. and Zahnert, T. Feasibility Study of a Mechanical Real-Time Feedback System for Optimizing the Sound Transfer in the Reconstructed Middle Ear. Otol Neurotol; 39(10), pp.907-920, 2018.

Mocanu, H., Bornitz, M., Lasurashvili, N. and Zahnert, T. Evaluation of Vibrant® Soundbridge™ positioning and results with laser doppler vibrometry and the finite element model. Exp Ther Med 202; 21 (3), pp.262, 2021. DOI: 10.3892/etm.2021.9694.

Rahn, H. and van Liew, H.D. Quoted from Studies in respiratory physiology. WADC Tech Repet 55-357. H. Rahn and W.O. Fenn eds., 382 Wright Air Development Center, Dayton, Ohio, 1955.

Ingelstedt, S. and Jonson, B. Mechanisms of the gas exchange in the normal human ME. Acta Otolaryngol [Suppl] (Stockh) suppl.; 224, pp.452-61, 1967.

Hamada, Y., Utahashi, H. and Aoki, K. Physiological gas exchange in the middle ear cavity. Int J Pediatr Otorhinolaryngol; 64, pp.41–9, 2002.

Marcusohn, Y., Ar, A. and Dirckx, J.J.J. Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case. Hear Res; 265, pp.11-4, 2010.

Doyle, W.J. Mathematical model explaining the sources of error in certain estimates of the gas exchange constants for the middle ear. Ann Otol Rhinol Laryngol; 109, pp.533-541, 2000.

Mover-Lev, H., Sadé, J. and Ar, A. Rate of gas exchange in the middle ear of guinea pigs. Ann Otol Rhinol Laryngol; 107, pp.194-8, 1998.


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