Unsuccessful driver performance can result in a traffic accident (TA) or avoidance. In this paper, the possible influence of the factors of driver fatigue on the performance of road vehicle drivers will be investigated. Deductive method, method of analysis and synthesis, and by compilation and comparing recent scientific and professional literature available new insights were made. Fatigue can degrade driver’s performance by reducing the maximum possible driver's capability to perform (e.g., chronic fatigue that affected the driver before performance) or by degrading the driver’s performance (passive fatigue due to monotonous fast road environment or dynamic fatigue due to traffic requirements from the environment). Driver fatigue is the factor that causes TA the most and it should be focused on more and mitigated with advanced driver assistance systems.

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