THE MAIN CHARACTERISTICS OF THE BIOMATERIALS COMPONENTS AND THE EXTRUSION METHOD MANUFACTURING TECHNOLOGY FOR PLA/HA BIOCOMPOSITE

Alexandru BEJINARU MIHOC, Ileana-Constanța ROȘCA

Abstract


The PLA/HA biocomposite material is a medical composite made of biomaterials in which the matrix is made of the biopolymer polylactic acid (PLA) and the bioceramic reinforcement (HA). Since the biopolymer (PLA) is completely bioresorbable and the bioceramic (HA), under normal conditions, is not degradable, the PLA/HA biocomposite is considered partially bioresorbable.  The paper presents the main characteristics of the two biomaterial components of the PLA/HA biocomposite, PLA biopolymer and bioceramics (HA), their fields of use in various medical applications and the manufacturing technology of the PLA/HA biocomposite, by the "extrusion" method.

Full Text:

PDF

References


Dorozhkin, V, S., Biocomposites and hybrid biomaterials based on calcium orthophosphates. În: Biomatter, vol.1, no. 1, pp. 3–56, 2011.

Dorozhkin, S. V. Calcium orthophosphate-based biocomposites and hybrid biomaterials. In: Journal of Materials Science, Vol.44, Issue, 9, pp. 2343–2387, 2009.

Ramakrishna, S., Mayer, J., Wintermantel, E., Leong, W. K., Biomedical applications of polymer-composite materials: a review. In: Composites Science and Technology, Vol. 61, No. 9, pp. 1189–1224, 2001.

Alizadeh-Osgouei, M., Li, Y., Wen, C. A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications. In: Bioactive Materials, No. 4, pp. 22–36, 2019.

Kroczek, K., Turek, P., Mazur, D., Szczygielski, J., Filip, D., Brodowski, R., Balawender, K., Przeszłowski, L., Lewandowski, B., Orkisz, S., et al. Characterisation of selected materials in medical applications. In: Polymers, Vol. 14, No. 1526, 2022.

Sin, L. T., Rahmat, Ab. R., Rahman, W. A. W. A. Polylactic acid PLA biopolymer technology and applications. ISBN: ISBN: 978-1-4377-4459-0, Ed. Elsevier, Oxford, USA, 2012.

Way, C. Fundamental understanding of polylactic acid –lignocellulose composites. Thesis, Swinburne University of Technology, Australia, 2014.

Nenitescu, C. D. Chimie organica. Vol. II, Editia a VII-a, Ed. Didactica si Pedagogica, Bucuresti, 1974.

Pawar, R. P., Tekale, S. U., Shisodia, S. U., Totre, J. T., Domb, A. J.

Biomedical applications of poly(lactic acid). In: Recent Patents on Regenerative Medicine, No. 4, pp. 40-51, 2014.

Manavitehrani, I., Fathi, A., Badr, H., Daly, S., Shirazi, N. A., Dehghani, F. Review. Biomedical applications of biodegradable polyesters. In: Polymers, vol. 8, no. 20, pp. 1-31, 2016.

Singhvi, M. S., Zinjarde, S.S., Gokhale, D.V. Polylactic acid: synthesis and biomedical applications. In: Journal of Applied Microbiology, No. 127, pp. 1612-1626, 2019.

Farah, Sh., Anderson, G. D., Langer, R. Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review. In: Advanced Drug Delivery Reviews, Vol. 107, pp. 367–392, 2016.

Perego, G., Cella, G. D. Mechanical properties. In: Poly(lactic acid): Synthesis, Structures, Properties, Processing, and Applications, edited by R. Auras, L.-T. Lim, S. E. M. Selke, and H. Tsuji, ch. 11, pp. 141-153. ISBN 978-0-470-29366-9, Ed. John Wiley & Sons, Inc., Hoboken, New Jersey, 2010.

DeStefano, V., Khan, S., Tabada, Al. Applications of PLA in modern medicine. In: Engineered Regeneration, No. 1, pp. 76–87, 2020.

Jamshidian, M., Tehrany, E. A., Imran, M., Jacquot, M., Desobry, St. Poly-Lactic Acid: Production, applications, nanocomposites, and release studies. In: Comprehensive Reviews in Food Science and Food Safety, Vol. 9, pp. 552-571, 2010.

Milovanovic, S., Pajnik, J., Lukic, I. Tailoring of advanced poly(lactic acid)-based materials: A review. In: Journal of Applied Polymer Science, Vol. 139, pp. 1-26, 2022. DOI: 10.1002/app.51839.

Jałbrzykowski, M., Minarowski, L., Krucińska, I., Herczyńska, L., Markiewicz, Gr. The influence of the injection moulding process on changes in selected physiochemical and mechanical properties of polyactide (PLA). In: Advances in manufacturing science and technology, Vol. 42, No. 1-4, pp. 1-12, 2018.

LeGeros, R. Z., LeGeros, J. P. Hydroxyapatite, ch.16, pp. 367-394. In: Bioceramics and their clinical applications, Eds. T. Kokubo, ISBN 978-1-84569-204-9, Ed. CRC Press, Boca Raton Boston New York Washington, DC, Cambridge, England, 2008.

Prakasam, M., Locs, J., Salma-Ancane, Kr., Loca, D., Largeteau, A., Berzina-Cimdina, L. Fabrication, properties and applications of dense hydroxyapatite: A review. In: Journal of Functional Biomaterials, no. 6, pp. 1099-1140, 2015.

Shors, E. C., Holmes, R. E. Porous hydroxyapatite, ch. 19, pp. 287-304. Eds. L. L. Hench, ISBN: 978-1-908977-15-1, Ed. Imperial College Press, London, 2013.

Bruijn De, J. D., Shankar, K., Yuan, H., Habibovic, P. Osteoinduction and its evaluation, ch. 9, pp. 183-198. In: Bioceramics and their clinical applications, Eds. T. Kokubo, ISBN 978-1-84569-204-9, Ed. CRC Press, Boca Raton Boston New York Washington, DC, Cambridge, England, 2008.

Barradas, A. M. C., Yuan, H., van Blitterswijk, C. A., Habibovic, P. Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms. In: European Cells and Materials, Vol. 21, pp. 407-429, 2011.

Tang, Z., Li, X., Tan, Y., Fan, H., Zhang, X. The material and biological characteristics of osteoinductive calcium phosphate ceramics. In: Regenerative Biomaterials, pp. 43–59, 2018.

Nakamura, T., Takemoto, M. Osteoconduction and its evaluation, ch. 9, pp. 199-219. In: Bioceramics and their clinical applications, Eds. T. Kokubo, ISBN 978-1-84569-204-9, Ed. CRC Press, Boca Raton Boston New York Washington, DC, Cambridge, England, 2008.

Jaramillo, C. D., Rivera, J. A., Echavarría, Al. E., O´byrne, J., Congote, D., Restrepo, L. F. Osteoconductive and osseointegration properties of a commercial hydroxyapatite compared to a synthetic product. In: Revista Colombiana de Ciencias Pecuarias, Vol. 23, pp. 471-483, 2010.

Gomes, D. S., Santos, A. M. C., Neves, G. A., Menezes, R. R. A brief review on hydroxyapatite production and use in biomedicine. In: Cerâmica, No. 65, pp. 282-302, 219.

Darsan, R. S., Retnam, B., Sivapragash, M. Material characteristic study and fabrication of hydroxyapatite (HA) with poly (Lactide/Lactic) acids (PLA) for orthopaedic implants. In: Middle-East Journal of Scientific Research, Vol. 25, No. 7, pp.1491-1500, 2017.

Murugan, R., Ramakrishna, S. Nanostructured biomaterials. In: Encyclopedia of nanoscience and nanotechnology, Ed. H. S. Nalwa, Vol. 7, No. 1, pp. 595-613, 2004.

He, L., Zhu, Ch., Wu, J., Liu, X. Hybrid composites of phosphate glass fibre/nano-hydroxyapatite/polylactide: Effects of nano-hydroxyapatite on mechanical properties and degradation behavior. In: Journal of Materials Science and Chemical Engineering, Vol.6, pp.13-31, 2018.

Fiume, E., Magnaterra, G., Rahdar, A., Verné, E., Baino, Fr. Hydroxyapatite for biomedical applications: A short overview. In: Ceramics, Vol. 4, pp. 542–563, 2021.

Lin, K., Chang, J. Structure and properties of hydroxyapatite for biomedical applications. In: Hydroxyapatite (HAp) for biomedical applications, ch.1, pp. 3-19. Eds. M. Mucalo, ISBN 978-1-78242-041-5 (online), Ed. Elsevier, New York, 2015.

Hench, L. L. Bioceramics: Research and Development Opportunities. In: Brazilian Journal of Physics, vol. 22, no. 2, pp. 70-76, 1992.

Park, J. B. Bioceramics. Properties, characterizations, and applications, ch. 9, pp. 184-205. ISBN: 978-0-387-09544-8, Ed. Springer, New York, 2008.

Majhooll , A. A., Zainol, I., Jaafar, C. N. A., Alsailawi, H. A., et al. A brief review on biomedical applications of hydroxyapatite use as fillers in polymer. In: Journal of Chemistry and Chemical Engineering, No.13, pp. 62-75, 2019.

Zimina, A., Senatov, F., Choudhary, R., Kolesnikov, E., Anisimova, N., Kiselevskiy, M., et al. Biocompatibility and physico-chemical properties of highly porous PLA/HA scaffolds for bone reconstruction. In: Polymers, Vol. 12, Issue 12, No. 2938, pp. 1-18, 2020.

Ferri, J. M., Jordá, J., Montanes, N., Fenollar, O., Balart, R. Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite. In: Journal of Thermoplastic Composite Materials, pp. 1–17, 2017.

Mohamed, Kh. R., Biocomposite materials. În: Composites and their applications, ch. 6, pp. 113-146. Eds. N. Hu, ISBN: 978-953-51-0706-4, Ed. Tech, Rijeka, Croatia, 2012.

***, Ingeo™ Biopolymer 6201D Technical Data Sheet. NatureWorks LLC, 15305 Minnetonka Blvd., Minnetonka, MN 55345.

***. Hydroxiapatite, https://www.sigmaaldrich.com/RO/en/product/aldrich/289396.


Refbacks

  • There are currently no refbacks.


JOURNAL INDEXED IN :